Description

Givinostat Hydrochloride is a potent and selective histone deacetylase (HDAC) inhibitor, specifically targeting Class I and II HDAC enzymes. This compound is a critical active pharmaceutical ingredient (API) and a valuable research tool for investigating epigenetic regulation and its role in disease pathways. It is primarily utilized by pharmaceutical developers and research institutions focused on oncology, neurology, and inflammatory conditions. The product is supplied under high-purity standards to ensure reliability for both research and development applications.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of investigational drugs targeting HDAC activity.
• Biomedical Research: Used as a reference standard and tool compound in epigenetic, cancer, and neurobiology research.
• Preclinical Development: Essential for in vitro and in vivo studies to establish pharmacokinetic and pharmacodynamic profiles.
• Process Chemistry & Scale-up: Serves as a key intermediate for process development and optimization in API manufacturing.
• Analytical Standard: High-purity material for method development, validation, and quality control (HPLC, LC-MS).

Basic Information

Product Name	Givinostat Hydrochloride
CAS No.	1019889-35-0
Molecular Formula	C₂₄H₂₇ClN₄O₄ • HCl
Molecular Weight	503.86 g/mol
Synonyms	Givinostat HCl; ITF2357 Hydrochloride; N-Hydroxy-4-[[(2S)-2-phenyl-2-(4-pyridinylcarbonylamino)acetyl]amino]methyl]benzamide Hydrochloride; HDAC Inhibitor IX, Hydrochloride; (2S)-N-Hydroxy-4-[[(2-hydroxy-1-phenylethyl)amino]methyl]-N'-2-pyridinylbenzene-1,4-dicarboxamide Hydrochloride
EINECS	Contact for details

Quality Control

Our Givinostat Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling by HPLC, to ensure it meets high-purity standards suitable for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.