Description

8-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridine is a high-value heterocyclic building block featuring a fused triazolopyridine core substituted with a trifluoromethyl group. This compound is strategically important for its role in modern pharmaceutical and agrochemical research, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in areas like kinase inhibitors, CNS agents, and anti-infectives.
• Agrochemical Research: Used in the design and synthesis of advanced herbicides, fungicides, and insecticides, leveraging the biological activity-enhancing properties of the CF3 group.
• Material Science Precursor: Serves as a specialized building block for creating functionalized ligands, organic semiconductors, or advanced polymers with unique electronic properties.
• Chemical Biology Probe: Employed in the construction of molecular probes and tags for studying biological systems and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects and scale-up activities.

Basic Information

Product Name	8-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
CAS No.	1019025-18-3
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	8-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine; 8-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine; [1,2,4]Triazolo[4,3-a]pyridine, 8-(trifluoromethyl)-; 8-Trifluoromethyl-[1,2,4]triazolo[4,3-a]pyridine; 8-Trifluoromethyl-1,2,4-triazolo[4,3-a]pyridine
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.