Description

4-Acetyl-3,4-Dihydro-2H-1,4-Benzoxazine-6-Sulfonyl Chloride is a high-value, reactive sulfonyl chloride derivative used as a critical synthetic intermediate. Its core value proposition lies in enabling the efficient introduction of the sulfonamide pharmacophore, a key structural motif in modern drug discovery. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly those developing novel active ingredients with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting enzyme inhibition via sulfonamide groups.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the benzoxazine-sulfonamide structure confers specific bioactivity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Material Science Research: Investigated as a monomer or cross-linking agent for creating specialized polymers with unique thermal or chemical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	4-Acetyl-3,4-Dihydro-2H-1,4-Benzoxazine-6-Sulfonyl Chloride
CAS No.	1017791-37-5
Molecular Formula	C10H10ClNO4S
Molecular Weight	275.71 g/mol
Synonyms	4-Acetyl-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonyl chloride; 2H-1,4-Benzoxazine-6-sulfonyl chloride, 4-acetyl-3,4-dihydro-; 4-Acetyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonyl chloride; 6-(Chlorosulfonyl)-4-acetyl-3,4-dihydro-2H-1,4-benzoxazine; N-Acetyl-6-chlorosulfonyl-3,4-dihydro-2H-1,4-benzoxazine
EINECS	Contact for details

Quality Control

Our 4-Acetyl-3,4-Dihydro-2H-1,4-Benzoxazine-6-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.