Description

4-Ethoxy-3-Fluorobenzene-1-Sulfonyl Chloride is a high-purity sulfonyl chloride derivative, a key synthetic intermediate in advanced organic chemistry. Its value lies in its reactivity as a versatile electrophile for introducing the sulfonamide or sulfonate moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in the development of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the sulfonamide group can confer specific biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Biology Probes: Employed in the creation of activity-based probes and labeling reagents for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Ethoxy-3-Fluorobenzene-1-Sulfonyl Chloride
CAS No.	1016756-58-3
Molecular Formula	C8H8ClFO3S
Molecular Weight	238.66 g/mol
Synonyms	3-Fluoro-4-ethoxybenzenesulfonyl chloride; 1-(Chlorosulfonyl)-2-fluoro-4-ethoxybenzene; 4-Ethoxy-3-fluorobenzenesulfonyl chloride; 2-Fluoro-4-ethoxybenzenesulfonyl chloride; CAS 1016756-58-3; 3-Fluoro-4-ethoxybenzene-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Ethoxy-3-Fluorobenzene-1-Sulfonyl Chloride is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO-guided applications, ensuring the material meets the stringent requirements of pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.