Description

4-Cyano-3-(Trifluoromethyl)Benzenesulfonyl Chloride is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its molecular structure, featuring both a reactive sulfonyl chloride group and electron-withdrawing cyano and trifluoromethyl substituents, makes it a critical intermediate for creating compounds with specific electronic and steric properties. This product is primarily sought by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and enzyme modulators.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides where the trifluoromethyl and sulfonyl groups enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, coatings, and advanced functional materials.
• Chemical Research & Development: A versatile reagent in medicinal chemistry and process chemistry for introducing the benzenesulfonyl moiety into complex molecular architectures.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where its substituents can alter color properties and lightfastness.

Basic Information

Product Name	4-Cyano-3-(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	1016701-95-3
Molecular Formula	C8H3ClF3NO2S
Molecular Weight	269.63 g/mol
Synonyms	4-Cyano-3-(trifluoromethyl)benzene-1-sulfonyl chloride; 3-(Trifluoromethyl)-4-cyanobenzenesulfonyl chloride; 4-Cyano-alpha,alpha,α-trifluoro-m-toluenesulfonyl chloride; 2-Cyano-5-(chlorosulfonyl)benzotrifluoride; 5-(Chlorosulfonyl)-2-(trifluoromethyl)benzonitrile; m-(Trifluoromethyl)-p-cyanobenzenesulfonyl chloride; Benzenesulfonyl chloride, 4-cyano-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 4-Cyano-3-(Trifluoromethyl)Benzenesulfonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with customer and regulatory requirements for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.