Description

4-Methoxy-3-(Propanamidomethyl)Benzene-1-Sulfonyl Chloride is a specialized sulfonyl chloride derivative, a key reactive intermediate in advanced organic synthesis. Its value lies in its ability to act as a versatile sulfonylation reagent, enabling the efficient introduction of the sulfonamide functional group into target molecules. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of sulfonamide-based drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the sulfonamide moiety imparts desired biological activity.
• Material Science Research: Employed in the creation of functional polymers, dyes, and advanced materials requiring specific sulfonated structures.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling proteins or modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Item	Details
Product Name	4-Methoxy-3-(Propanamidomethyl)Benzene-1-Sulfonyl Chloride
CAS No.	1016497-18-9
Molecular Formula	C11H14ClNO4S
Molecular Weight	291.75 g/mol
Synonyms	3-(Propanoylamidomethyl)-4-methoxybenzenesulfonyl chloride; 4-Methoxy-3-(propionamidomethyl)benzenesulfonyl chloride; 1-(Chlorosulfonyl)-2-methoxy-5-(propionamidomethyl)benzene; 2-Methoxy-5-(propionamidomethyl)benzenesulfonyl chloride; 1016497-18-9; Propanamide, N-[(2-methoxy-5-(chlorosulfonyl)phenyl)methyl]-
EINECS	Contact for details

Quality Control

Our production of 4-Methoxy-3-(Propanamidomethyl)Benzene-1-Sulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your synthetic workflows. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.