Description

4-(Benzyloxy)-3-Fluorobenzene-1-Sulfonyl Chloride is a high-purity, specialized sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual functional groups, enabling precise and efficient introduction of the sulfonyl moiety into target molecules under controlled conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides and fungicides, leveraging the sulfonyl group for enhanced biological activity.
• Material Science Research: Employed in the creation of specialty polymers and functional materials requiring sulfonated aromatic structures.
• Chemical Biology Probes: Acts as a reactive handle for labeling proteins or modifying biomolecules in probe development.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects requiring fluorinated benzyl-protected intermediates.

Basic Information

Product Name	4-(Benzyloxy)-3-Fluorobenzene-1-Sulfonyl Chloride
CAS No.	1016492-60-6
Molecular Formula	C₁₃H₁₀ClFO₃S
Molecular Weight	300.73 g/mol
Synonyms	3-Fluoro-4-(phenylmethoxy)benzenesulfonyl chloride; 4-(Benzyloxy)-3-fluorobenzenesulfonyl chloride; 1-(Benzyloxy)-2-fluoro-4-(chlorosulfonyl)benzene; 3-Fluoro-4-benzyloxybenzenesulfonyl chloride; 4-Benzyloxy-3-fluorophenylsulfonyl chloride; 1016492-60-6; 3-Fluoro-4-(benzyloxy)benzene-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxy)-3-Fluorobenzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.