Description

Tildacerfont CAS NO 1014983-00-6 is a high-purity, nonpeptide corticotropin-releasing factor type 1 (CRF1) receptor antagonist. This compound is of significant interest for its targeted mechanism of action in regulating the hypothalamic-pituitary-adrenal (HPA) axis. It is primarily utilized by pharmaceutical research and development organizations engaged in the discovery and synthesis of novel therapeutics for endocrine and stress-related disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting CRF1 receptors.
• Preclinical Research: Used in in vitro and in vivo studies to investigate the role of CRF1 in stress response, anxiety, depression, and addiction pathways.
• Reference Standard: Employed as an analytical standard in method development and quality control for drug substance and product testing.
• Mechanism of Action Studies: Facilitates research into HPA axis dysregulation and the development of potential treatments for conditions like Cushing's syndrome.
• Biochemical Assay Development: Acts as a key ligand in high-throughput screening (HTS) campaigns and receptor binding assays.

Basic Information

Product Name	Tildacerfont
CAS No.	1014983-00-6
Molecular Formula	C23H23F3N4O2
Molecular Weight	444.45 g/mol
Synonyms	NBI-77860; 4-(3-Pentylphenyl)-2,4-dihydro-5-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one; 4-(3-Pentylphenyl)-5-[2-(trifluoromethyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; Tildacerfontum; UNII-6J9V6S8U4M; 6J9V6S8U4M
EINECS	Contact for details

Quality Control

Our Tildacerfont is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.