Description

Tenovin-6 is a potent and selective small molecule inhibitor of SIRT1 and SIRT2, key enzymes in the sirtuin family involved in cellular regulation. This compound matters for its role as a critical research tool in probing the mechanisms of aging, stress response, and oncogenesis, offering significant value in drug discovery and basic biological research. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, neurodegenerative diseases, and metabolic disorders. Tenovin-6 CAS NO 1011557-82-6 represents a high-purity chemical for advancing therapeutic and diagnostic development.

Application

• Biochemical Research: Used as a specific sirtuin inhibitor to study gene silencing, DNA repair, and cellular senescence pathways.
• Oncology Research: Investigated for its potential to induce p53-dependent apoptosis in cancer cell lines and tumor models.
• Neurodegenerative Disease Studies: Applied in research exploring the role of protein acetylation in conditions like Alzheimer's and Parkinson's disease.
• Metabolic Disorder Research: Utilized to examine the connection between sirtuin activity, insulin signaling, and lifespan regulation.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool for validating sirtuin targets in preclinical assays.
• Cell Biology Assays: Employed in vitro and in cell culture to modulate histone and non-histone protein acetylation states.

Basic Information

Product Name	Tenovin-6
CAS No.	1011557-82-6
Molecular Formula	C22H29N3O2S
Molecular Weight	399.55 g/mol
Synonyms	Tenovin 6; Tenovin-6; N-(3-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)thio)-1H-indol-5-yl)acetamide; 3-((2,3-Dihydro-1,4-benzodioxin-6-yl)thio)-N-(1H-indol-5-yl)propanamide; SIRT1/2 Inhibitor III; Sirtuin Inhibitor, Tenovin-6
EINECS	Contact for details

Quality Control

Our Tenovin-6 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.