Description

Tenovin 6 (Hydrochloride) is a potent and selective small molecule inhibitor of SIRT1 and SIRT2, key enzymes in the sirtuin family involved in cellular regulation. This compound matters for its critical role in modulating protein deacetylation, impacting pathways related to cell survival, metabolism, and aging. It is primarily needed by researchers and developers in the pharmaceutical, biotechnology, and life science industries for drug discovery, target validation, and fundamental biochemical studies.

Application

• Biochemical Research: Used as a key tool compound for studying sirtuin biology, protein acetylation/deacetylation dynamics, and related epigenetic mechanisms.
• Oncology Research: Investigated for its potential to induce p53-dependent apoptosis and cell cycle arrest in various cancer cell models.
• Neurodegenerative Disease Research: Applied in studies exploring the role of sirtuins in conditions like Alzheimer's and Parkinson's disease.
• Metabolic Disorder Studies: Utilized in research targeting metabolic pathways influenced by SIRT1, such as glucose homeostasis and lipid metabolism.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for developing novel therapeutics targeting sirtuin activity.
• Cell Biology Assays: Employed in in vitro and cell-based assays to probe the functional consequences of sirtuin inhibition.

Basic Information

Product Name	Tenovin 6 (Hydrochloride)
CAS No.	1011301-29-3
Molecular Formula	C22H29N3O2S • HCl
Molecular Weight	436.01 g/mol
Synonyms	Tenovin-6 HCl; Tenovin6 hydrochloride; N-(2-Mercapto-5-(trifluoromethyl)phenyl)-3-(pyridin-3-yl)acrylamide hydrochloride; SIRT1/2 Inhibitor VI; Sirtuin Inhibitor, Tenovin-6; 3-(3-Pyridinyl)-N-[2-mercapto-5-(trifluoromethyl)phenyl]-2-propenamide hydrochloride
EINECS	Contact for details

Quality Control

Our Tenovin 6 (Hydrochloride) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.