Description

Maritoclax CAS NO 1010732-14-5 is a potent and selective small-molecule inhibitor of Mcl-1, a key anti-apoptotic protein in the Bcl-2 family. This compound is of significant interest for its potential to overcome resistance to other Bcl-2 family inhibitors, making it a critical research tool in oncology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel cancer therapeutics and studying programmed cell death mechanisms.

Application

• Oncology Research: A vital biochemical tool for studying the role of Mcl-1 in cancer cell survival, apoptosis resistance, and tumor progression.
• Drug Discovery & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in preclinical studies for novel anti-cancer agents.
• Mechanistic Studies: Enables investigation of Bcl-2 protein family interactions and the intrinsic apoptosis pathway in various cell lines.
• Combination Therapy Research: Explored in studies to sensitize cancer cells to conventional chemotherapeutics or other targeted agents by inhibiting Mcl-1.
• Biomarker Research: Supports research into Mcl-1 expression levels as a potential biomarker for cancer prognosis and treatment response.
• High-Throughput Screening (HTS): Serves as a control compound in assays designed to discover new Mcl-1 inhibitors.

Basic Information

Product Name	Maritoclax
CAS No.	1010732-14-5
Molecular Formula	C₂₆H₂₈ClN₃O₃
Molecular Weight	465.97 g/mol
Synonyms	Maritoclax; 1010732-14-5; UNII-1F8V0C6V8C; 1F8V0C6V8C; Marinopyrrole A; (S)-Maritoclax; Mcl-1 inhibitor; Apoptosis activator
EINECS	Contact for details

Quality Control

Every batch of Maritoclax is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support your research, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment to ensure traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.