Description

Cx-4945 is a potent and selective small molecule inhibitor of Casein Kinase 2 (CK2), a serine/threonine kinase implicated in numerous cellular processes. This compound is a critical research tool for investigating CK2's role in cell signaling, proliferation, and survival pathways. It is primarily utilized by researchers in the fields of oncology, neurology, and molecular biology for target validation, mechanism-of-action studies, and preclinical drug discovery.

Application

• Biochemical Research: Used as a selective CK2 inhibitor to study kinase signaling pathways and enzyme function in vitro.
• Cancer Research: Investigated for its effects on tumor cell growth, apoptosis, and as a potential chemotherapeutic agent in preclinical models.
• Neurobiological Studies: Applied in research exploring CK2's role in neuronal development, synaptic plasticity, and neurodegenerative diseases.
• Pharmaceutical R&D: Serves as a reference standard and a lead compound for the development of novel kinase-targeted therapeutics.
• Cell Biology: Utilized to modulate CK2 activity to understand its impact on the cell cycle, DNA repair, and transcription regulation.

Basic Information

Product Name	Cx-4945
CAS No.	1009820-21-6
Molecular Formula	C₂₁H₂₃N₅O₂
Molecular Weight	377.44 g/mol
Synonyms	5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid; Silmitasertib; CX-4945 sodium salt (pro-drug form); Casein Kinase II Inhibitor IV; CK2 Inhibitor Cx-4945
EINECS	Contact for details

Quality Control

Our Cx-4945 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and analytical results are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.