Description

Largazole is a potent and selective Class I histone deacetylase (HDAC) inhibitor originally isolated from marine cyanobacteria. This compound matters for its significant role as a chemical probe in epigenetic research and as a lead structure in the discovery of novel anticancer therapeutics. Researchers and developers in the pharmaceutical and biotechnology sectors need it for its unique mechanism of action, which modulates gene expression and influences cell cycle progression. Largazole CAS NO 1009815-87-5 represents a high-value tool for advancing oncology and epigenetics studies.

Application

• As a reference standard in analytical method development and validation for pharmaceutical quality control.
• Utilized as a potent biochemical tool for studying histone deacetylase (HDAC) enzyme activity and inhibition mechanisms.
• Critical in epigenetic and cancer research to investigate cell differentiation, proliferation, and apoptosis pathways.
• Serves as a lead compound in medicinal chemistry programs for the design of novel HDAC-targeted therapeutics.
• Used in in vitro and in vivo preclinical studies to evaluate antitumor efficacy and pharmacokinetic properties.

Basic Information

Product Name	Largazole
CAS No.	1009815-87-5
Molecular Formula	C₂₉H₄₂N₄O₄S₂
Molecular Weight	574.79 g/mol
Synonyms	Largazole; Largazole (cyclic depsipeptide); HDAC Inhibitor VIII; (4S,7S,10S,16S,19S,22S,28S,31S)-7,16,22,31-Tetraisobutyl-4,10,19,28-tetramethyl-3,6,9,12,15,18,21,24,27,30-decaoxo-1-thia-5,8,11,14,17,20,23,26,29-nonaazacyclodotriacontane-2-thione; Cyclic depsipeptide Largazole
EINECS	Contact for details

Quality Control

Our Largazole is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be kept in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.