Description

Razuprotafib is a potent and selective small-molecule inhibitor of the protein kinase AKT, also known as Protein Kinase B. This compound is a critical research tool for investigating the PI3K/AKT/mTOR signaling pathway, which plays a central role in cell growth, proliferation, and survival. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, metabolic disease, and signal transduction research.

Application

• Biomedical Research: A key pharmacological probe for studying the role of AKT isoforms in cancer biology, cellular signaling networks, and drug resistance mechanisms.
• Drug Discovery & Development: Used as a reference standard and lead compound in preclinical studies for developing novel targeted cancer therapies.
• Mechanistic Studies: Essential for in vitro and in vivo experiments to validate AKT as a therapeutic target and understand pathway crosstalk.
• High-Throughput Screening (HTS): Employed as a control compound in assay development and screening campaigns to identify new AKT inhibitors.

Basic Information

Product Name	Razuprotafib
CAS No.	1008510-37-9
Molecular Formula	C₂₃H₂₃N₅O₃
Molecular Weight	417.46 g/mol
Synonyms	AKT inhibitor VIII; ARQ 092; ARQ-092; ARQ092; (S)-1-(4-((4-(Dimethylamino)piperidin-1-yl)sulfonyl)phenyl)-3-(4-(4-methylthiazol-5-yl)pyridin-2-yl)urea; UNII-0B6R456P6S
EINECS	Contact for details

Quality Control

Our Razuprotafib is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our rigorous specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.