Description

Hydrocodone-D3 is a deuterated isotopologue of the semi-synthetic opioid analgesic hydrocodone, where three hydrogen atoms are replaced by deuterium. This stable-labeled internal standard is critical for ensuring the accuracy and reliability of quantitative analysis in complex biological matrices. It is an essential reference material for pharmaceutical research, forensic toxicology, and clinical laboratories conducting drug monitoring and pharmacokinetic studies. The compound's high isotopic purity and chemical stability make it indispensable for precise mass spectrometry-based assays.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for hydrocodone analysis.
• Forensic Toxicology: Used in the confirmation and quantification of hydrocodone in post-mortem and human performance testing (e.g., DUID cases).
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables accurate measurement of hydrocodone and its metabolites in patient plasma or serum for pharmacokinetic studies and dose optimization.
• Pharmaceutical Development: Supports bioanalytical method development and validation for new drug formulations containing hydrocodone.
• Metabolite Studies: Facilitates the investigation of hydrocodone metabolism pathways and the identification of novel metabolites.
• Reference Standard for Regulatory Compliance: Serves as a certified reference material for laboratories adhering to FDA, EMA, or other regulatory guidelines for controlled substance testing.

Basic Information

Product Name	Hydrocodone-D3
CAS No.	1007854-30-9
Molecular Formula	C18H18D3NO3
Molecular Weight	302.39 g/mol (approx.)
Synonyms	4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one-D3; Dihydrocodeinone-D3; 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one (phenyl-d3); Hydrocodone (phenyl-d3); Hydrocodone-d3 (phenyl-d3); Norcodeine Impurity D-D3; Stable Labeled Hydrocodone-D3
EINECS	Contact for details

Quality Control

Our Hydrocodone-D3 is manufactured under strict quality systems to ensure the highest standards for analytical reference materials. Each batch undergoes comprehensive testing, including determination of isotopic purity (≥99 atom % D), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). A detailed Certificate of Analysis (COA) is provided, which includes batch-specific data and traceability. Production adheres to relevant guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label/COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % D
Chemical Purity	≥95%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.