Description

Smurf1 Inhibitor A01 CAS NO 1007647-73-5 is a potent and selective small molecule inhibitor designed to target the Smurf1 (Smad ubiquitination regulatory factor 1) E3 ubiquitin ligase. This compound is a critical research tool for modulating the ubiquitin-proteasome pathway, which plays a fundamental role in regulating protein degradation, cell signaling, and various disease states. It is essential for researchers and developers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on cancer biology, bone metabolism, and neurodegenerative disease research.

Application

• Biomedical Research: Used as a key pharmacological agent to study the role of Smurf1 in TGF-β/BMP signaling pathways, cell proliferation, and differentiation.
• Oncology Research: Investigated for its potential to inhibit tumor growth and metastasis by targeting Smurf1-mediated degradation of tumor suppressor proteins.
• Bone Disease Studies: Applied in research models for osteoporosis and bone regeneration to understand Smurf1's regulation of osteoblast and osteoclast activity.
• Neurodegenerative Disease Research: Utilized in studies exploring protein aggregation and clearance mechanisms relevant to Alzheimer's and Parkinson's diseases.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for novel therapeutic agents.
• Cell Culture & In Vitro Assays: Employed to manipulate protein stability and signaling outcomes in controlled laboratory experiments.

Basic Information

Item	Detail
Product Name	Smurf1 Inhibitor A01
CAS No.	1007647-73-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Smurf1 Inhibitor A01; A01 Smurf1 Inhibitor; Smurf1 E3 Ligase Inhibitor A01; 1007647-73-5; Smad Ubiquitination Regulatory Factor 1 Inhibitor; [Additional IUPAC/chemical names available upon request]
EINECS	Contact for details

Quality Control

Our Smurf1 Inhibitor A01 is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation, to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.