Description

1-(2,2-Difluoroethyl)-3,5-Dimethyl-1H-Pyrazole-4-Sulfonyl Chloride is a high-purity, functionalized pyrazole derivative serving as a critical sulfonylating reagent and advanced pharmaceutical intermediate. Its value lies in enabling the precise synthesis of complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the sulfonyl chloride moiety under controlled conditions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-containing drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the research and production of modern herbicides and fungicides that require the incorporation of a difluoroethyl-pyrazole scaffold.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling proteins or synthesizing activity-based probes (ABPs) due to its sulfonyl chloride functionality.
• Material Science Research: Employed in the development of novel polymers or functional materials where the sulfonyl group can modify material properties.
• Custom Synthesis & Contract Manufacturing: Serves as a specialized starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	1-(2,2-Difluoroethyl)-3,5-Dimethyl-1H-Pyrazole-4-Sulfonyl Chloride
CAS No.	1006487-24-6
Molecular Formula	C7H9ClF2N2O2S
Molecular Weight	254.67 g/mol
Synonyms	1-(2,2-Difluoroethyl)-3,5-dimethyl-1H-pyrazole-4-sulfonyl chloride; 3,5-Dimethyl-1-(2,2-difluoroethyl)-1H-pyrazole-4-sulfonyl chloride; 4-Pyrazolesulfonyl chloride, 1-(2,2-difluoroethyl)-3,5-dimethyl-; 1H-Pyrazole-4-sulfonyl chloride, 1-(2,2-difluoroethyl)-3,5-dimethyl-; DFEP-SCl; 1-(2,2-Difluoroethyl)-3,5-dimethylpyrazole-4-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 1-(2,2-Difluoroethyl)-3,5-Dimethyl-1H-Pyrazole-4-Sulfonyl Chloride is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.