Description

1-(2,2-Difluoroethyl)-1H-Pyrazole-4-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile electrophilic reagent for introducing the 1-(2,2-difluoroethyl)pyrazole-4-sulfonyl moiety, a key functional group in advanced material and pharmaceutical development. This compound is essential for researchers and manufacturers in the agrochemical and pharmaceutical industries, particularly for the synthesis of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoroethyl-pyrazole scaffold provides unique biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialized polymers and advanced functional materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling proteins or modifying biomolecules in probe development and biochemical assays.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(2,2-Difluoroethyl)-1H-Pyrazole-4-Sulfonyl Chloride
CAS No.	1006487-21-3
Molecular Formula	C5H5ClF2N2O2S
Molecular Weight	234.62 g/mol
Synonyms	1-(2,2-Difluoroethyl)-1H-pyrazole-4-sulfonyl chloride; 1H-Pyrazole-4-sulfonyl chloride, 1-(2,2-difluoroethyl)-; 1-(Difluoroethyl)pyrazole-4-sulfonyl chloride; 4-(Chlorosulfonyl)-1-(2,2-difluoroethyl)-1H-pyrazole; 1-(2,2-Difluoroethyl)-4-sulfonylchloride-pyrazole
EINECS	Contact for details

Quality Control

Every batch of 1-(2,2-Difluoroethyl)-1H-Pyrazole-4-Sulfonyl Chloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) including HPLC purity, identity confirmation (NMR, IR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.