Description

[3-Cyclopropyl-6-(1,5-Dimethyl-1H-Pyrazol-4-Yl)-4-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating pyrazole and pyridine motifs. This compound is of significant commercial interest due to its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially for targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• API Synthesis: A key building block in the multi-step production of complex active pharmaceutical ingredients.
• Biochemical Research: Potential use as a tool compound or probe for investigating biological pathways and enzyme interactions.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	[3-Cyclopropyl-6-(1,5-Dimethyl-1H-Pyrazol-4-Yl)-4-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid
CAS No.	1006444-33-2
Molecular Formula	C₁₈H₁₆F₃N₅O₂
Molecular Weight	391.35 g/mol
Synonyms	1H-Pyrazolo[3,4-b]pyridine-1-acetic acid, 3-cyclopropyl-6-(1,5-dimethyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)-; (3-Cyclopropyl-6-(1,5-dimethyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid; 1006444-33-2; 3-Cyclopropyl-6-(1,5-dimethyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-ylacetic Acid
EINECS	Contact for details

Quality Control

Our [3-Cyclopropyl-6-(1,5-Dimethyl-1H-Pyrazol-4-Yl)-4-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.