Description

L-Methionine-34S is a stable isotope-labeled analog of the essential amino acid L-Methionine, where the sulfur atom is replaced by the stable isotope sulfur-34. This compound is a critical tool for advanced research and analytical applications requiring precise metabolic tracing and quantification. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, nutritional science, and stable isotope labeling for mass spectrometry.

Application

• Stable Isotope Labeling in Mass Spectrometry (MS): Used as an internal standard for the accurate quantification of methionine and its metabolites in complex biological matrices via LC-MS and GC-MS.
• Metabolic Pathway Tracing: Enables detailed studies of sulfur-containing amino acid metabolism, protein synthesis, and transmethylation cycles in cell culture, animal models, and clinical research.
• Pharmaceutical Research & Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the incorporation and fate of methionine in novel therapeutic compounds.
• Nutritional and Biomedical Research: Facilitates investigations into human nutrition, metabolic disorders, and the role of methionine in health and disease states.
• Proteomics and Protein Dynamics: Used in Stable Isotope Labeling by Amino acids in Cell culture (SILAC) experiments to study protein turnover, synthesis rates, and post-translational modifications.
• Quality Control Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Item	Detail
Product Name	L-Methionine-34S
CAS No.	1006386-95-3
Molecular Formula	C5H11NO234S
Molecular Weight	151.21 g/mol (for 34S isotope)
Synonyms	(2S)-2-Amino-4-(methylsulfanyl-[34S])butanoic acid; L-2-Amino-4-(methylthio-[34S])butyric acid; L-Methionine (34S); Methionine-34S; [34S]-L-Methionine; Stable Isotope Labeled L-Methionine; L-Met-34S
EINECS	Contact for details

Quality Control

Our L-Methionine-34S is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, isotopic enrichment (typically >98 atom% 34S), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (34S)	≥98 atom%
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	+21.0° to +25.0° (c=1 in 1N HCl)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.