Description

6-Oxo-5-Trifluoromethyl-1,6-Dihydro-Pyridine-2-Carboxylic Acid Methyl Ester is a high-value fluorinated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a trifluoromethyl group and a lactam moiety, makes it indispensable for constructing complex molecules with enhanced biological activity and physicochemical properties. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science Precursor: Employed in the development of specialty chemicals, liquid crystals, and functional materials requiring fluorinated heterocycles.
• Organic Synthesis Reagent: Acts as a versatile scaffold for further functionalization, including cross-coupling reactions, nucleophilic substitutions, and ring transformations in academic and industrial labs.

Basic Information

Product Name	6-Oxo-5-Trifluoromethyl-1,6-Dihydro-Pyridine-2-Carboxylic Acid Methyl Ester
CAS No.	1006364-88-0
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	Methyl 6-oxo-5-(trifluoromethyl)-1,6-dihydropyridine-2-carboxylate; 5-Trifluoromethyl-6-oxo-1,6-dihydro-2-pyridinecarboxylic acid methyl ester; 2-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-5-(trifluoromethyl)-, methyl ester; Methyl 5-(trifluoromethyl)-6-oxo-1,6-dihydro-2-pyridinecarboxylate; 1,6-Dihydro-6-oxo-5-(trifluoromethyl)-2-pyridinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 6-Oxo-5-Trifluoromethyl-1,6-Dihydro-Pyridine-2-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure consistency and reliability. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific customer requirements for research or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.