Description

6-Methoxy-4-(trifluoromethyl)nicotinaldehyde is a high-value, multi-functional chemical building block characterized by its nicotinaldehyde core substituted with methoxy and trifluoromethyl groups. This compound is critical for the synthesis of complex molecules, offering chemists a versatile handle for constructing heterocyclic scaffolds and introducing the metabolically stable trifluoromethyl group. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine moiety and the lipophilicity of the CF3 group.
• Material Science: Serves as a building block for advanced organic materials, such as ligands for catalysis or components in organic electronics.
• Chemical Synthesis: The aldehyde functionality allows for further derivatization via condensation, reduction, or cyclization reactions to create diverse heterocyclic libraries.
• Academic & Contract Research: Employed in universities and CROs for methodological development and exploratory synthesis projects.

Basic Information

Item	Details
Product Name	6-Methoxy-4-(trifluoromethyl)nicotinaldehyde
CAS No.	1005171-85-6
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	4-(Trifluoromethyl)-6-methoxynicotinaldehyde; 6-Methoxy-4-(trifluoromethyl)pyridine-3-carbaldehyde; 3-Formyl-6-methoxy-4-(trifluoromethyl)pyridine; 6-Methoxy-4-trifluoromethylnicotinaldehyde; 6-Methoxy-4-trifluoromethyl-3-pyridinecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 6-Methoxy-4-(trifluoromethyl)nicotinaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to handle under an inert atmosphere and store under nitrogen for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.