Description

Pdk1 Inhibitor CAS NO 1001409-50-2 is a potent and selective small molecule inhibitor of 3-phosphoinositide-dependent protein kinase-1 (PDK1), a key regulator in the PI3K/AKT signaling pathway. This compound is a critical research tool for investigating cellular processes related to cell growth, survival, and metabolism, with significant implications for oncology and metabolic disease research. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on signal transduction and targeted therapeutic development.

Application

• Biochemical Research: Used as a selective probe to study the role of PDK1 in the PI3K/AKT/mTOR signaling cascade in vitro.
• Cell-Based Assays: Applied in cellular models to investigate the effects of PDK1 inhibition on cell proliferation, apoptosis, and glucose metabolism.
• Target Validation: Serves as a pharmacological tool for validating PDK1 as a therapeutic target in various disease models, including cancer and diabetes.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and hit-to-lead optimization programs for developing novel PDK1-targeted therapeutics.
• Mechanistic Studies: Facilitates research into downstream effector pathways, such as SGK and PKC, which are also activated by PDK1.
• Preclinical Research: Employed in animal model studies to evaluate the efficacy and pharmacokinetics of PDK1 inhibition in vivo.

Basic Information

Product Name	Pdk1 Inhibitor CAS NO 1001409-50-2
CAS No.	1001409-50-2
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	PDK1 Inhibitor; 2-(2-Amino-9H-purin-9-yl)-5-[(4-fluorophenyl)thio]-3H-thiazolo[4,5-d]pyrimidin-7(6H)-one; BX-795; BX 795; BX795; PDK-1 Inhibitor; 3-Phosphoinositide-dependent kinase-1 Inhibitor; UNII-2K5K2N8Q4M; 2K5K2N8Q4M
EINECS	Contact for details

Quality Control

Our Pdk1 Inhibitor is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and potency is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.