Description

2-(Chloromethyl)-1-Fluoro-3-(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound matters for its unique trifluoromethyl and chloromethyl substituents, which enable precise molecular modifications critical for developing novel materials and active ingredients. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs for enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce reactive chloromethyl and stable fluorinated groups into polymer chains, altering surface properties, chemical resistance, and durability.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex, fluorinated biaryl structures.
• Chemical Research & Development: An essential tool in medicinal and process chemistry for exploring new chemical spaces and optimizing synthetic routes.

Basic Information

Product Name	2-(Chloromethyl)-1-Fluoro-3-(Trifluoromethyl)Benzene
CAS No.	1001096-10-1
Molecular Formula	C9H5ClF4
Molecular Weight	224.58 g/mol
Synonyms	1-Fluoro-2-(chloromethyl)-3-(trifluoromethyl)benzene; 2-Chloromethyl-1-fluoro-3-trifluoromethylbenzene; α-Chloro-2-fluoro-6-(trifluoromethyl)benzyl chloride; 2-Fluoro-6-(trifluoromethyl)benzyl chloride; 1-(Chloromethyl)-2-fluoro-3-(trifluoromethyl)benzene; 2-Fluoro-α-(chloromethyl)-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 2-(Chloromethyl)-1-Fluoro-3-(Trifluoromethyl)Benzene is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.