Description

8-Fluoroquinoline-5-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, enabling the introduction of both the fluorinated quinoline scaffold and a sulfonamide linkage, which is essential for modulating the biological activity and physicochemical properties of target molecules. This intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in drug discovery programs targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those requiring a sulfonamide pharmacophore for enhanced binding affinity.
• Agrochemical Research: Used in developing new herbicides, fungicides, or insecticides where the quinoline-sulfonamide structure can confer specific biological activity.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Bioconjugation Chemistry: The reactive sulfonyl chloride group enables labeling and modification of biomolecules (e.g., proteins, peptides) for diagnostic or research purposes.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and mechanism within biological systems.
• Library Synthesis: Employed in combinatorial and parallel synthesis to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	8-Fluoroquinoline-5-Sulfonyl Chloride
CAS No.	1000933-89-0
Molecular Formula	C9H5ClFNO2S
Molecular Weight	245.66 g/mol
Synonyms	8-Fluoro-5-quinolinesulfonyl chloride; Quinoline-5-sulfonyl chloride, 8-fluoro-; 8-Fluoroquinoline-5-sulfonylchloride; 5-Quinolinesulfonyl chloride, 8-fluoro-; 8-Fluoro-5-sulfochloroquinoline
EINECS	Contact for details

Quality Control

Our 8-Fluoroquinoline-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment is to supply material that meets the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.