Description

2-(Bromomethyl)-5-(Trifluoromethyl)Pyridine is a versatile and high-value brominated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and a stable trifluoromethyl moiety, makes it indispensable for introducing functional complexity into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct advanced pyridine-based herbicides, fungicides, and insecticides, leveraging the biological activity enhancement provided by the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a starting material for creating novel nitrogen-containing ligands for transition metal catalysis and organocatalysts.
• Material Science Research: Employed in the development of functional organic materials, such as liquid crystals and electronic chemicals, where its halogen and fluorine atoms tune material properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromomethyl handle.
• Fluorine Chemistry Building Block: The trifluoromethyl group makes it a valuable synthon for introducing fluorine atoms into complex molecules to improve metabolic stability and lipophilicity.

Basic Information

Product Name	2-(Bromomethyl)-5-(Trifluoromethyl)Pyridine
CAS No.	1000773-62-5
Molecular Formula	C7H5BrF3N
Molecular Weight	240.02 g/mol
Synonyms	5-(Trifluoromethyl)-2-pyridinemethanol, bromo derivative; 2-(Bromomethyl)-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-(bromomethyl)pyridine; 2-Pyridinemethanol, 5-(trifluoromethyl)-, bromo derivative; (5-(Trifluoromethyl)pyridin-2-yl)methyl bromide
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.