Description

1-Bromo-2-Chloro-5-Fluoro-3-Methylbenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is needed by R&D chemists and process development scientists for creating active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its unique halogen substitution pattern.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for screening.
• Fluorine Chemistry: The presence of the fluorine atom makes it valuable for studying structure-activity relationships (SAR) and metabolic stability in bioactive molecules.

Basic Information

Item	Details
Product Name	1-Bromo-2-Chloro-5-Fluoro-3-Methylbenzene
CAS No.	1000576-68-0
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	2-Bromo-1-Chloro-5-Fluoro-3-Methylbenzene; 3-Methyl-2-Bromo-1-Chloro-5-Fluorobenzene; 5-Fluoro-2-Bromo-1-Chloro-3-Methylbenzene; 1-Chloro-2-Bromo-5-Fluoro-3-Methylbenzene; BCFM-Benzene (abbrev.); Benzene, 1-bromo-2-chloro-5-fluoro-3-methyl-; 2-Chloro-6-bromo-4-fluorotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-5-Fluoro-3-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.