Description

3-Bromo-2-Fluoro-6-Iodotoluene is a highly functionalized halogenated toluene derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique combination of bromo, fluoro, and iodo substituents on the aromatic ring makes it exceptionally valuable for introducing specific halogen atoms or for participating in cross-coupling reactions. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the halogen atoms are crucial for bioactivity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and bromine atoms are excellent substrates for Suzuki, Stille, and Negishi cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry: The fluorine atom provides a metabolically stable point for further derivatization, making it valuable in medicinal chemistry for improving drug potency and pharmacokinetics.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for biological screening.

Basic Information

Product Name	3-Bromo-2-Fluoro-6-Iodotoluene
CAS No.	1000576-29-3
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	1-Bromo-2-fluoro-3-iodo-4-methylbenzene; 2-Fluoro-3-bromo-6-iodotoluene; 3-Bromo-2-fluoro-6-iodo-1-methylbenzene; Toluene, 3-bromo-2-fluoro-6-iodo-; 4-Methyl-1-bromo-2-fluoro-3-iodobenzene; 6-Iodo-3-bromo-2-fluorotoluene
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoro-6-Iodotoluene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.