Description

(5-Trifluoromethyl-Pyridin-3-Yl)-Acetic Acid CAS NO 1000516-17-5 is a high-value pyridine derivative and trifluoromethylated building block of significant interest in advanced organic synthesis. Its core value lies in its ability to introduce both a nitrogen-containing heterocycle and a metabolically stable trifluoromethyl group into target molecules, which is crucial for modulating physicochemical properties. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of functionalized organic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	(5-Trifluoromethyl-Pyridin-3-Yl)-Acetic Acid
CAS No.	1000516-17-5
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	2-(5-(Trifluoromethyl)pyridin-3-yl)acetic acid; 3-Pyridineacetic acid, 5-(trifluoromethyl)-; (5-Trifluoromethyl-3-pyridyl)acetic acid; 5-(Trifluoromethyl)nicotinic acid, acetic acid derivative; TFMPAA; [3-(Carboxymethyl)-5-(trifluoromethyl)pyridine]
EINECS	Contact for details

Quality Control

Our (5-Trifluoromethyl-Pyridin-3-Yl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.