Description

2-Chloro-1-Methanesulfonyl-4-(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic building block characterized by its sulfonyl chloride and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced agrochemicals and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce sulfonamide and trifluoromethyl motifs into novel molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers and liquid crystals that require specific electronic properties.
• Cross-Coupling Reactions: An electrophilic partner in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form complex biaryl systems.
• Sulfonylation Agent: Acts as a reagent to introduce the methanesulfonyl group into nucleophilic substrates under controlled conditions.
• Fluorine Chemistry: A valuable building block in medicinal chemistry for exploring the "fluorine effect" to improve drug potency and pharmacokinetics.

Basic Information

Product Name	2-Chloro-1-Methanesulfonyl-4-(Trifluoromethyl)Benzene
CAS No.	1000339-68-3
Molecular Formula	C8H6ClF3O2S
Molecular Weight	258.65 g/mol
Synonyms	1-Chloro-2-(methanesulfonyl)-4-(trifluoromethyl)benzene; 2-Chloro-α,α,α-trifluoro-4-(methylsulfonyl)toluene; 4-(Trifluoromethyl)-2-chlorophenyl methyl sulfone; 2-Chloro-4-(trifluoromethyl)phenyl methyl sulfone; 1-Chloro-4-(trifluoromethyl)-2-(methylsulfonyl)benzene; 2-Chloro-1-(methylsulfonyl)-4-(trifluoromethyl)benzene; Methyl 2-chloro-4-(trifluoromethyl)phenyl sulfone
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-Methanesulfonyl-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.