Description

2-(2,6-Dioxo-Piperidin-1-Yl)-Ethanesulfonyl Chloride is a high-purity sulfonyl chloride derivative, a critical building block in advanced organic synthesis. Its primary value lies in its dual reactive sites, enabling its use as a versatile linker and reagent for constructing complex molecules, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for API development and scale-up.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for targeted protein degradation (PROTAC) molecules and other novel therapeutic modalities.
• Bioconjugation Reagent: Used to create stable covalent linkages between biomolecules (e.g., antibodies, peptides) and payloads such as drugs, dyes, or polymers.
• Polymer Chemistry: Serves as a functional monomer or cross-linking agent for producing specialty polymers with specific sulfonamide or sulfonate functionalities.
• Agrochemical Synthesis: Intermediate in the development of new herbicides, fungicides, and insecticides requiring a sulfonyl chloride moiety.
• Material Science Research: Employed in surface modification and the creation of advanced functional materials with tailored properties.
• Chemical Biology Probes: Utilized to develop activity-based probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	2-(2,6-Dioxo-Piperidin-1-Yl)-Ethanesulfonyl Chloride
CAS No.	1000339-13-8
Molecular Formula	C7H10ClNO4S
Molecular Weight	239.68 g/mol
Synonyms	1-(2-Chloroethanesulfonyl)piperidine-2,6-dione; 2-(2,6-Dioxopiperidin-1-yl)ethanesulfonyl chloride; 1-(2-Chloroethylsulfonyl)glutarimide; N-(2-Chloroethanesulfonyl)glutarimide; Glutarimide-1-ethanesulfonyl chloride; 2,6-Piperidinedione, 1-(2-chloroethylsulfonyl)-; 1-(2-Chloroethanesulfonyl)-2,6-piperidinedione
EINECS	Contact for details

Quality Control

Our 2-(2,6-Dioxo-Piperidin-1-Yl)-Ethanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.