Description

Cyclo(Arg-Gly-Asp-D-Phe-Val) Tfa is a synthetic, cyclic peptide integrin inhibitor, a key research tool in cell biology and oncology. This compound, with CAS number 199807-33-5, is highly valued for its potent and selective antagonism of αvβ3 and αvβ5 integrins, which are critical in angiogenesis and tumor metastasis. It is an essential reagent for researchers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on cancer therapeutics, anti-angiogenic drug discovery, and cellular adhesion studies.

Application

• Cancer Research & Anti-Angiogenesis Studies: Used as a reference standard and active agent to inhibit tumor-induced angiogenesis by blocking αvβ3/αvβ5 integrin signaling pathways.
• Cell Adhesion & Migration Assays: Employed in vitro to study the role of RGD-binding integrins in cellular processes like adhesion, spreading, and migration on extracellular matrix proteins.
• Pharmaceutical Development: Serves as a lead compound or pharmacophore model for the design and screening of novel anti-cancer and anti-metastatic drugs.
• Biomaterial & Tissue Engineering: Applied in surface modification studies to create bioactive or anti-adhesive coatings by mimicking or blocking integrin recognition sites.
• Signal Transduction Research: A critical tool for dissecting downstream signaling cascades (e.g., FAK, Src) activated by integrin-ligand interactions.
• In Vivo Model Studies: Utilized in animal models to evaluate the efficacy of integrin-targeted therapies for cancer, osteoporosis, and inflammatory diseases.

Basic Information

Product Name	Cyclo(Arg-Gly-Asp-D-Phe-Val) Tfa
CAS No.	199807-33-5
Molecular Formula	C34H50N12O8 • C2HF3O2
Molecular Weight	828.85 g/mol (as TFA salt)
Synonyms	c(RGDfV); Cyclo(Arg-Gly-Asp-D-Phe-Val); cRGDfV peptide; Cyclo(RGDfV); Cyclo(-Arg-Gly-Asp-D-Phe-Val-); Cilengitide precursor; TFA salt of Cyclo(Arg-Gly-Asp-D-Phe-Val); αvβ3 Integrin Inhibitor, Cyclic RGDfV
EINECS	Contact for details

Quality Control

Our Cyclo(Arg-Gly-Asp-D-Phe-Val) Tfa is manufactured under strict quality systems suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, content, and analytical data are provided to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.