Description

Givinostat Hydrochloride is a potent and selective histone deacetylase (HDAC) inhibitor, supplied as the hydrochloride salt for enhanced stability and handling. This compound is a critical research-grade active pharmaceutical ingredient (API) for investigating novel therapeutic pathways, particularly in oncology and inflammatory diseases. It is essential for pharmaceutical R&D, preclinical studies, and academic research focused on epigenetic modulation and drug discovery.

Application

• Pharmaceutical Research & Development (R&D): Primary use as a reference standard and active ingredient in the development of novel HDAC inhibitor therapies.
• Preclinical & In-Vitro Studies: Investigation of anti-cancer, anti-inflammatory, and anti-fibrotic mechanisms in cell-based assays and animal models.
• Biochemical Research: Tool compound for studying histone deacetylase enzyme activity, chromatin remodeling, and gene expression regulation.
• Academic Research: Fundamental research in epigenetics, oncology, and molecular biology within university and institutional laboratories.
• Process Development: Sourcing material for analytical method development, formulation studies, and stability testing in pharmaceutical manufacturing.

Basic Information

Product Name	Givinostat Hydrochloride
CAS No.	199657-29-9
Molecular Formula	C₂₄H₂₇N₃O₄ • HCl
Molecular Weight	473.95 g/mol
Synonyms	ITF2357 Hydrochloride; Givinostat HCl; N-Hydroxy-4-[[(2S)-2-({[4-(Trifluoromethyl)phenyl]sulfonyl}amino)-3-(trifluoromethyl)benzoyl]amino]butanamide Hydrochloride; HDAC Inhibitor ITF2357; (2S)-N-Hydroxy-4-[[2-[[[4-(trifluoromethyl)phenyl]sulfonyl]amino]-3-(trifluoromethyl)benzoyl]amino]butanamide Hydrochloride
EINECS	Contact for details

Quality Control

Our Givinostat Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP standards for API manufacturing where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.