Description

Dihydro-Artemisinin Glucuronide is a key glucuronide metabolite of the potent antimalarial agent, Dihydroartemisinin. This compound is of significant importance in pharmaceutical research and development, particularly for studying the pharmacokinetics, metabolism, and bioavailability of artemisinin-based therapies. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling precise analytical work and the development of new therapeutic formulations.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for quantitative and qualitative analysis in drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolite Research: Essential for investigating the metabolic pathways, clearance mechanisms, and biological activity of Dihydroartemisinin and related artemisinin derivatives.
• Bioanalytical Method Development: Serves as a critical component in developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for biological sample analysis.
• Impurity Profiling: Employed in the identification and quantification of process-related impurities or degradation products in antimalarial drug substances and products.
• Preclinical & Clinical Studies: Utilized in non-clinical and clinical research to understand exposure-response relationships and support regulatory submissions for new drug applications.
• Chemical Synthesis Intermediate: Acts as a building block or precursor for the synthesis of novel chemical entities or labeled analogs for tracer studies.

Basic Information

Item	Details
Product Name	Dihydro-Artemisinin Glucuronide
CAS No.	198976-06-6
Molecular Formula	C21H32O10
Molecular Weight	444.47 g/mol
Synonyms	Dihydroartemisinin Glucuronide; Dihydroartemisinin β-D-Glucuronide; Arteannuin B Glucuronide; Artemisininin Glucuronide Metabolite; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one β-D-Glucopyranosiduronic Acid; α-Dihydroartemisinin Glucuronide
EINECS	Contact for details

Quality Control

Our Dihydro-Artemisinin Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications. We support cGMP standards for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term storage, keep at 2-8°C. The product is light-sensitive (store away from light). Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.