Description

Z-Phe-Dl-Ala-Fluoromethylketone is a specialized fluoromethyl ketone derivative designed as a potent and irreversible protease inhibitor. This compound is critical for biochemical research, enabling the study of enzyme mechanisms and the development of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on protease-related disease pathways.

Application

• Protease Inhibition Studies: Serves as a key biochemical tool for investigating the activity and inhibition mechanisms of serine and cysteine proteases.
• Drug Discovery & Development: Used in high-throughput screening and lead optimization for diseases where protease activity is dysregulated.
• Enzyme Mechanism Research: Enables detailed kinetic and structural analysis of enzyme active sites and catalytic pathways.
• Biochemical Assay Development: Acts as a reference standard or active control in developing and validating in vitro enzymatic assays.
• Apoptosis & Cell Signaling Research: Applied in studies of programmed cell death and intracellular signaling cascades involving proteolytic enzymes.
• Infectious Disease Research: Investigated for potential antiviral or antimicrobial applications targeting pathogen-specific proteases.

Basic Information

Product Name	Z-Phe-Dl-Ala-Fluoromethylketone
CAS No.	197855-65-5
Molecular Formula	C21H23FN2O5
Molecular Weight	402.42 g/mol
Synonyms	Z-Phe-Ala-FMK; Benzyloxycarbonyl-Phenylalanyl-Alanyl-Fluoromethyl Ketone; N-(Benzyloxycarbonyl)-L-phenylalanyl-DL-alanine fluoromethyl ketone; FMK Inhibitor Z-FA; Caspase Inhibitor Z-FA-FMK; Protease Inhibitor Z-Phe-Ala-CH2F; Z-FA-FMK; Z-Phe-Ala-fluoromethylketone
EINECS	Contact for details

Quality Control

Our Z-Phe-Dl-Ala-Fluoromethylketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.