Description

Exatecan Mesylate is a potent, water-soluble derivative of the topoisomerase I inhibitor camptothecin, designed to enhance stability and therapeutic efficacy. This compound is of significant interest for its role in advanced pharmaceutical research and development, particularly in oncology. It serves as a critical intermediate and active pharmaceutical ingredient (API) for researchers and manufacturers developing novel anti-cancer therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of novel camptothecin-derived anti-cancer drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate topoisomerase I inhibition mechanisms and cell apoptosis.
• Preclinical Development: Serves as a reference standard and active material in formulation studies, pharmacokinetics, and toxicology assessments for new drug candidates.
• API Manufacturing: Employed as the active pharmaceutical ingredient in the production of targeted cancer therapies under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation Studies: Utilized in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems to improve cancer cell specificity.

Basic Information

Product Name	Exatecan Mesylate
CAS No.	197720-53-9
Molecular Formula	C₂₄H₂₇N₃O₈S • CH₄O₃S
Molecular Weight	597.62 g/mol
Synonyms	DX-8951f; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonate; Exatecan methanesulfonate; DX 8951f; DX8951f
EINECS	Contact for details

Quality Control

Our Exatecan Mesylate is produced and tested to meet the stringent requirements of pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure consistency and reliability. Certificates of Analysis (COA) are provided, detailing all specifications and test results. We adhere to a quality management system to support our commitment to supplying high-purity materials for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.