Description

Igf-1R Inhibitor II, n-(5-Chloro-2-Methoxyphenyl)-N'-(2-Methylquinolin-4-yl)Urea is a potent and selective small molecule inhibitor of the Insulin-like Growth Factor 1 Receptor (IGF-1R), a key target in oncology research. This compound is crucial for studying signal transduction pathways involved in cell proliferation, survival, and tumorigenesis, offering significant value in preclinical drug discovery. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel cancer therapeutics. The product is supplied with high purity and batch-to-batch consistency to ensure reliable experimental results.

Application

• Biochemical Research: Used as a selective tool compound to inhibit IGF-1R kinase activity in cell-based and enzymatic assays.
• Oncology Drug Discovery: Serves as a reference standard and lead compound in the development of targeted cancer therapies, particularly for solid tumors.
• Signal Pathway Analysis: Employed to elucidate the role of the IGF-1R pathway in cellular processes and its crosstalk with other oncogenic pathways.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate the efficacy and mechanism of action of IGF-1R inhibition.
• High-Throughput Screening (HTS): Acts as a control or validation compound in screening campaigns for new IGF-1R inhibitors.
• Academic Research: Supports fundamental research into growth factor biology, metabolic disorders, and cancer biology.

Basic Information

Item	Detail
Product Name	Igf-1R Inhibitor II, n-(5-Chloro-2-Methoxyphenyl)-N'-(2-Methylquinolin-4-yl)Urea
CAS No.	196868-63-0
Molecular Formula	C24H19ClN4O2
Molecular Weight	430.89 g/mol
Synonyms	N-(5-Chloro-2-methoxyphenyl)-N'-(2-methylquinolin-4-yl)urea; IGF-1R Inhibitor II; IGF1R Inhibitor II; BMS-536924 analog; CAS 196868-63-0; 4-Quinolineurea, N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-; UNII-9J8F3856WY
EINECS	Contact for details

Quality Control

Our Igf-1R Inhibitor II is manufactured under strict quality management systems to ensure the highest standards for research use. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results for traceability and reproducibility in your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.