Description

Bay 11-7085 is a potent and selective small molecule inhibitor of IκBα phosphorylation, effectively suppressing NF-κB activation. This compound is a critical research tool for studying inflammatory signaling pathways, apoptosis, and cellular responses to stress. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for drug discovery and mechanistic studies.

Application

• Biomedical Research: Used as a key pharmacological agent to inhibit NF-κB in studies of inflammation, immune response, and cancer biology.
• Drug Discovery & Development: Serves as a reference compound and lead molecule in screening assays and target validation for novel anti-inflammatory therapeutics.
• Cell Signaling Studies: Essential for elucidating the role of the IKK/IκB/NF-κB pathway in various disease models, including autoimmune disorders and neurodegenerative diseases.
• Academic & Institutional Research: Employed in university and research institute laboratories for fundamental biological research and publication.
• Biotech Reagent Production: Supplied to manufacturers of assay kits, cell-based screening systems, and other research consumables.

Basic Information

Product Name	Bay 11-7085
CAS No.	196309-76-9
Molecular Formula	C₁₆H₁₄N₂O₃
Molecular Weight	282.30 g/mol
Synonyms	(E)-3-(4-Methylphenyl)sulfonyl-2-propenenitrile; BAY 11-7085; BAY 11-7082; BAY11-7085; IKK-2 Inhibitor IV; NF-κB Activation Inhibitor; (E)-3-[4-(Methylsulfonyl)phenyl]-2-propenenitrile; 3-[(E)-2-Cyanoethenyl]benzenesulfonamide
EINECS	Contact for details

Quality Control

Every batch of Bay 11-7085 is produced and analyzed under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.