Description

2-(Difluoromethyl)-1,4-Difluorobenzene is a specialized fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its value lies in the strategic placement of fluorine atoms and a difluoromethyl group, which are critical for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates where fluorine substitution is advantageous.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the difluoromethyl moiety can improve biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a fluorine-containing core structure in the synthesis of advanced liquid crystals for display technologies.
• Organic Electronics: Employed as a building block for electron-deficient aromatic units in the development of organic semiconductors and photovoltaic materials.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the synthesis of specialty polymers with unique surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce a fluorinated phenyl group into complex molecular architectures.

Basic Information

Product Name	2-(Difluoromethyl)-1,4-Difluorobenzene
CAS No.	195886-79-4
Molecular Formula	C7H4F4
Molecular Weight	164.10 g/mol
Synonyms	1,4-Difluoro-2-(difluoromethyl)benzene; 2-(Difluoromethyl)-1,4-difluorobenzene; 1,4-Difluoro-2-difluoromethylbenzene; Benzene, 1,4-difluoro-2-(difluoromethyl)-; α,α,2,5-Tetrafluorotoluene; 2,5-Difluorobenzylidene Fluoride; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethyl)-1,4-Difluorobenzene is produced and analyzed under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.