Description

Ethanone, 2,2,2-Trifluoro-1-[4-(2-Hydroxyethyl)Phenyl]- (9Ci) is a specialized trifluoromethyl ketone derivative, a high-value intermediate prized for its unique combination of a reactive carbonyl group, a fluorinated moiety, and a terminal hydroxyl group. This compound matters for its role in advanced synthesis, where it serves as a key building block for pharmaceuticals, agrochemicals, and functional materials, enabling the introduction of trifluoromethyl groups to enhance metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), enhancing thermal stability and electronic properties.
• Polymer & Resin Modifier: Incorporated as a monomer or cross-linking agent to create specialty polymers with improved chemical resistance, weatherability, and surface properties.
• Advanced Organic Synthesis: Employed in asymmetric synthesis, catalysis research, and as a scaffold for constructing complex heterocyclic compounds in academic and industrial R&D settings.
• Fluorinated Surfactant & Coating Precursor: Acts as a key intermediate for synthesizing fluorosurfactants and high-performance coatings that require oil, water, and stain repellency.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-[4-(2-Hydroxyethyl)Phenyl]- (9Ci)
CAS No.	193418-14-3
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	1-[4-(2-Hydroxyethyl)phenyl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-(2-hydroxyethyl)phenyl]ethanone; 4-(2-Hydroxyethyl)phenyl trifluoromethyl ketone; 2-(4-Trifluoroacetylphenyl)ethanol; Trifluoroacetylphenethyl alcohol; TFAPEA; CAS 193418-14-3
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2,2-Trifluoro-1-[4-(2-Hydroxyethyl)Phenyl]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.