Description

Tasidotin is a synthetic dolastatin 15 analogue and a potent microtubule inhibitor with significant antineoplastic activity. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the research and development of novel cancer therapeutics. It is primarily utilized by pharmaceutical companies, biotechnology research firms, and academic institutions focused on oncology drug discovery and preclinical studies. The compound, identified by CAS No. 192658-64-3, represents a key building block in the synthesis of targeted chemotherapeutic agents.

Application

• Oncology Research & Drug Discovery: Serves as a primary lead compound or intermediate in the development of novel antimitotic and anti-tubulin chemotherapeutic agents.
• Preclinical Pharmaceutical Development: Used in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and toxicity profiles of new cancer treatments.
• Biochemical Research: Employed as a tool compound to study microtubule dynamics, cell cycle arrest, and mechanisms of apoptosis in cancer cell lines.
• API Synthesis: Acts as a crucial intermediate in the multi-step synthesis of advanced pharmaceutical candidates targeting solid tumors and hematological malignancies.
• Reference Standard: Used as a high-purity analytical standard for quality control, method development, and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	Tasidotin
CAS No.	192658-64-3
Molecular Formula	C34H57N5O6
Molecular Weight	631.85 g/mol
Synonyms	Synthadotin; ILX-651; (2S)-2-[(2S)-2-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]amino]-N-[(1S,2R)-1-[(cyclopropylamino)carbonyl]-2-hydroxypropyl]pentanediamide; Dolastatin 15 Analogue; Tasidotin Hydrochloride (salt form); Cemadotin analogue; NSC-710305
EINECS	Contact for details

Quality Control

Our Tasidotin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.