Description

Oblimersen Sodium CAS NO 190977-41-4 is a synthetic antisense oligonucleotide designed to target the Bcl-2 mRNA, playing a critical role in regulating apoptosis. This compound is of significant interest for its potential in targeted therapeutic research, particularly in oncology. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on developing novel cancer treatments and studying apoptotic pathways.

Application

• Oncology Research: Key investigational agent for studying apoptosis inhibition and developing novel cancer therapies.
• Pharmaceutical Development: Used as an active pharmaceutical ingredient (API) or intermediate in the formulation of antisense-based therapeutics.
• Biochemical Research: Serves as a critical tool for investigating Bcl-2 protein expression and function in cellular models.
• Preclinical Studies: Employed in in vitro and in vivo studies to evaluate efficacy and mechanism of action for hematologic and solid tumors.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in laboratories.

Basic Information

Product Name	Oblimersen Sodium
CAS No.	190977-41-4
Molecular Formula	C204H243N63Na19O114P18S18
Molecular Weight	Contact for details
Synonyms	Oblimersen; G3139; Bcl-2 Antisense Oligonucleotide G3139; Augmerosen; Genasense; 2'-Deoxy-2'-fluoro-D-ribose, oligonucleotide, 5'-P-[5-[2-[[[2-[(aminocarbonyl)amino]ethyl]amino]carbonyl]-1H-pyrrol-1-yl]-2,5-dideoxy-2-fluoro-D-ribofuranosyl] deriv.; ISIS 112989; BMS-275291
EINECS	Contact for details

Quality Control

Our Oblimersen Sodium is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.