Description

Rhein Acyl-β-D-Glucuronide is a specific glucuronide metabolite of Rhein, a key bioactive anthraquinone found in traditional medicinal herbs. This compound is of significant interest for its role in pharmacokinetic and metabolic studies, providing a crucial reference standard for accurate analysis. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug metabolism research, bioanalytical method development, and the quality control of herbal extracts.

Application

• Pharmacokinetic and ADME Studies: Serves as a critical reference standard for quantifying Rhein and its metabolites in biological matrices like plasma and urine.
• Bioanalytical Method Development: Used for the validation and calibration of HPLC, LC-MS, and LC-MS/MS methods in pharmaceutical R&D.
• Herbal Medicine Research: Acts as a marker compound for the standardization and quality control of herbal extracts containing Rhein, such as those from Rhubarb or Senna.
• Drug Metabolism Investigation: Essential for studying the Phase II conjugation pathways (glucuronidation) of anthraquinone-based drug candidates.
• Reference Material Production: Supplied to manufacturers of certified reference materials (CRMs) and high-purity standards for analytical laboratories.

Basic Information

Product Name	Rhein Acyl-β-D-Glucuronide
CAS No.	190605-03-9
Molecular Formula	C21H16O12
Molecular Weight	460.34 g/mol
Synonyms	Rhein 8-O-β-D-glucuronide; Rhein Acyl Glucuronide; 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid 8-(β-D-glucopyranuronosyl) ester; Cassic acid Acyl-β-D-Glucuronide; Rhein-8-Glucuronide; (8-Glucuronosyl) Rhein; Rhein Glucuronide Metabolite
EINECS	Contact for details

Quality Control

Our Rhein Acyl-β-D-Glucuronide is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for reference standard materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.