Description

Epothilone D CAS NO 189453-10-9 is a potent, naturally occurring microtubule-stabilizing agent belonging to the macrolide class. This compound matters as a highly promising lead candidate in oncology research, offering a distinct mechanism of action from taxanes and potential efficacy against multidrug-resistant cancers. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in the discovery and development of next-generation chemotherapeutic agents.

Application

• Anticancer Drug Discovery: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical research for novel oncology therapeutics.
• Mechanism of Action Studies: Used in biochemical and cellular assays to investigate microtubule dynamics, polymerization, and stabilization.
• Structure-Activity Relationship (SAR) Research: Acts as a core scaffold for the synthesis and biological evaluation of novel epothilone analogs.
• Overcoming Drug Resistance: Investigated for its efficacy in models of cancers resistant to paclitaxel and other conventional chemotherapies.
• Biomedical Research Reagent: Employed as a critical tool compound in cell biology to study mitosis, cell cycle arrest, and apoptosis.
• Process Chemistry & Scale-Up: Used in the development and optimization of synthetic routes for the production of epothilone-based APIs.

Basic Information

Product Name	Epothilone D
CAS No.	189453-10-9
Molecular Formula	C27H41NO6S
Molecular Weight	507.68 g/mol
Synonyms	Epothilone D; KOS-862; NSC-703147; 4,8-Dimethyl-12-(2-methyl-4-thiazolyl)-13-oxa-4,8-diazabicyclo[13.2.2]nonadeca-1(17),15(18),16-triene-5,9,14,19-tetrone; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
EINECS	Contact for details

Quality Control

Our Epothilone D is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended for long-term storage. Keep container tightly sealed under an inert atmosphere when handling to minimize exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.