Description

Dynorphin A (1-10)-Gly-Chloromethylketone is a potent and selective synthetic peptide inhibitor designed for advanced biochemical and pharmacological research. This compound serves as a crucial tool for investigating the kappa opioid receptor (KOR) system and related neurobiological pathways. It is primarily utilized by research scientists and pharmaceutical developers in the fields of neuroscience, pain management, and neuropsychiatric disorder research to study receptor-ligand interactions and enzyme inhibition mechanisms.

Application

• Neuroscience Research: A key reagent for studying the role of dynorphin and the kappa opioid receptor (KOR) in pain signaling, stress response, and reward pathways.
• Enzyme Inhibition Studies: Used as an active site-directed irreversible inhibitor to probe the function of specific proteases and convertases involved in peptide hormone processing.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in the screening and development of novel analgesics and neurotherapeutics targeting the opioid system.
• Biochemical Assay Development: Employed in the design and validation of in vitro assays to measure enzyme activity or receptor binding affinity.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on neuropeptides, signal transduction, and molecular pharmacology.

Basic Information

Product Name	Dynorphin A (1-10)-Gly-Chloromethylketone
CAS No.	189002-98-0
Molecular Formula	C58H86N16O13
Molecular Weight	1199.4 g/mol
Synonyms	Dynorphin A (1-10) Gly Chloromethyl Ketone; Dynorphin A(1-10)-Gly-CMK; [Gly11]-Dynorphin A (1-11) chloromethyl ketone; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Gly-CMK; Kappa Opioid Receptor Peptide Inhibitor; Chloromethylketone inhibitor of dynorphin converting enzyme; DYN A-(1-10)-Gly-CMK
EINECS	Contact for details

Quality Control

Every batch of Dynorphin A (1-10)-Gly-Chloromethylketone is manufactured and analyzed under strict quality protocols to ensure the highest standards of purity and consistency for research applications. Our quality assurance includes comprehensive analytical testing via HPLC and mass spectrometry. A detailed Certificate of Analysis (COA) providing batch-specific data on purity, identity, and impurities is supplied with each order to support your regulatory and experimental documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, acetic acid solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.