Description

Sc-560 CAS NO 188817-13-2 is a potent and selective cyclooxygenase-1 (COX-1) inhibitor, widely recognized in biochemical and pharmacological research. This compound is a critical tool for investigating the distinct roles of COX-1 and COX-2 isoforms in inflammatory pathways, pain signaling, and cellular processes. It is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors who require high-purity, well-characterized chemical probes for target validation and mechanistic studies.

Application

• Pharmacological Research: Used as a selective COX-1 inhibitor to dissect the specific contributions of COX-1 in various disease models, including inflammation, pain, and fever.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel non-steroidal anti-inflammatory drugs (NSAIDs) with improved selectivity profiles.
• Biochemical Assays: Employed in in vitro enzyme inhibition studies to determine IC50 values and assess the selectivity of new chemical entities against COX-1.
• Cell Biology Studies: Utilized to study the role of COX-1-derived prostanoids in cellular functions such as platelet aggregation, gastric cytoprotection, and renal homeostasis.
• Academic & Institutional Research: A key reagent for university and research institute labs focusing on eicosanoid biology, signal transduction, and molecular pharmacology.
• Preclinical Studies: Applied in animal models to investigate the physiological and pathophysiological roles of COX-1, helping to validate it as a therapeutic target.

Basic Information

Product Name	Sc-560
CAS No.	188817-13-2
Molecular Formula	C₂₃H₂₀ClF₃N₂O₃
Molecular Weight	488.87 g/mol
Synonyms	5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole; SC-560; COX-1 Inhibitor III; 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)pyrazole; Selective COX-1 inhibitor; 1H-Pyrazole, 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-; MFCD00274512
EINECS	Contact for details

Quality Control

Our Sc-560 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool, and well-ventilated place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.