Description

Bcr-Abl-In-1 CAS NO 188260-50-6 is a potent and selective small molecule inhibitor designed to target the Bcr-Abl tyrosine kinase, a key oncogenic driver in certain leukemias. This compound is a critical research tool for studying kinase signaling pathways and developing novel therapeutic strategies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology and kinase biology.

Application

• Biochemical Research: Used as a reference standard and active agent in enzymatic assays to study Bcr-Abl kinase inhibition and mechanism of action.
• Cell-Based Studies: Applied in cellular models of chronic myeloid leukemia (CML) and other Bcr-Abl-positive cancers to evaluate anti-proliferative effects and signal transduction blockade.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for the design and synthesis of next-generation tyrosine kinase inhibitors (TKIs).
• Preclinical Pharmacology: Employed in in vitro and in vivo studies to establish proof-of-concept, dose-response relationships, and preliminary efficacy data.
• High-Throughput Screening (HTS): Utilized as a control compound in screening campaigns to identify novel scaffolds with Bcr-Abl inhibitory activity.
• Structure-Activity Relationship (SAR) Analysis: Provides a core structure for medicinal chemistry efforts aimed at optimizing potency, selectivity, and pharmacokinetic properties.

Basic Information

Product Name	Bcr-Abl-In-1
CAS No.	188260-50-6
Molecular Formula	C₂₃H₂₅N₅O₂
Molecular Weight	403.48 g/mol
Synonyms	Bcr-Abl Inhibitor 1; 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide; AG 957; NSC 680410; Tyrphostin AG 957; Bcr-Abl tyrosine kinase inhibitor AG957
EINECS	Contact for details

Quality Control

Our Bcr-Abl-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and NMR/LC-MS for structural identity, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.