Description

Caspase Inhibitor3 CAS NO 187389-53-3 is a potent and selective cell-permeable inhibitor of caspase-3 (CPP32/apopain) and related caspases. This compound is critical for researchers investigating apoptotic pathways, as it effectively blocks the execution phase of programmed cell death. It is an essential tool for pharmaceutical R&D, academic research, and biotechnology applications focused on neuroprotection, ischemia-reperfusion injury, and inflammatory disease models.

Application

• Apoptosis Research: Fundamental tool for studying caspase-3 mediated cell death pathways in vitro and in vivo.
• Neuroprotective Studies: Used in models of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's, ALS) to inhibit neuronal apoptosis.
• Ischemia-Reperfusion Injury Models: Applied in cardiac and cerebral ischemia research to reduce tissue damage.
• Inflammatory Disease Research: Investigates the role of caspases in inflammatory conditions like sepsis and rheumatoid arthritis.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening for novel caspase inhibitors.
• Cell Biology & Biochemistry: Used to elucidate specific caspase functions in cellular signaling and protein cleavage assays.

Basic Information

Product Name	Caspase Inhibitor3
CAS No.	187389-53-3
Molecular Formula	C20H28N4O7
Molecular Weight	460.46 g/mol
Synonyms	Z-DEVD-FMK; Caspase-3 Inhibitor II; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone; DEVD-FMK; Caspase 3/7 Inhibitor; Apoptosis Inhibitor III; (2S)-5-[[(2S)-4-[[(2S)-1-[[(2S)-4-Amino-1-[[(2S)-1-(benzyloxy)-3-fluoro-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]amino]-3-methoxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our Caspase Inhibitor3 is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological potency. We adhere to relevant quality standards for research chemicals, ensuring material integrity for critical life science applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Biological Activity (IC50)	≤ 20 nM (Caspase-3)
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.