Description

Z-Vad-Fmk is a potent, cell-permeable, and irreversible pan-caspase inhibitor widely used in biochemical and pharmaceutical research. This compound is essential for studying the mechanisms of apoptosis (programmed cell death) and for developing therapeutic strategies for related diseases. It is a critical research tool for scientists in the fields of oncology, neurobiology, and immunology, where precise control of apoptotic pathways is required.

Application

• Apoptosis Research: Used as a standard inhibitor to block caspase activity and confirm the role of caspases in cell death pathways.
• Drug Discovery & Screening: Employed in high-throughput screening assays to identify novel pro-apoptotic or anti-apoptotic compounds.
• Neurodegenerative Disease Studies: Applied in models of stroke, Alzheimer's, and Parkinson's disease to investigate caspase-mediated neuronal death.
• Cancer Biology: Utilized to study chemoresistance and to protect cells from apoptosis in various experimental setups.
• Inflammation & Immunology: Helps in dissecting the role of caspases in inflammatory cell death (pyroptosis) and immune responses.
• Biochemical Assay Development: Serves as a positive control in enzymatic assays for characterizing caspase inhibitors and activators.

Basic Information

Product Name	Z-Vad-Fmk
CAS No.	187389-52-2
Molecular Formula	C22H31FN4O6
Molecular Weight	466.50 g/mol
Synonyms	Z-VAD-FMK; Z-VAD(OMe)-FMK; Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone; Caspase Inhibitor Z-VAD-FMK; Z-Val-Ala-Asp(OMe)-FMK; Z-VAD-FMK (Pan-Caspase Inhibitor); N-Benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone; Z-VAD(OMe)-CH2F
EINECS	Contact for details

Quality Control

Our Z-Vad-Fmk is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to relevant quality management standards to support our global clientele in academic, pharmaceutical, and biotechnology sectors.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.