Description

Irofulven is a potent, semi-synthetic derivative of the fungal metabolite illudin S, representing a significant class of sesquiterpenoid anticancer agents. Its primary value lies in its unique mechanism of action, which induces DNA damage and apoptosis in rapidly dividing cells, making it a compound of high interest for advanced therapeutic research. This product is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on developing novel oncology treatments and studying cellular response mechanisms.

Application

• Oncology Research & Drug Development: As a key investigational compound for studying novel anti-cancer mechanisms and evaluating efficacy in various cancer cell lines.
• Biochemical Pathway Analysis: Used to investigate cellular apoptosis, DNA damage response, and stress signaling pathways in experimental models.
• Preclinical Studies: Serves as a critical active pharmaceutical ingredient (API) in formulation development and in vivo efficacy testing for potential cancer therapeutics.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, and NMR for quality control and method validation in pharmaceutical analysis.
• Medicinal Chemistry: Provides a core scaffold for the synthesis and structure-activity relationship (SAR) study of new derivatives with optimized pharmacological profiles.

Basic Information

Product Name	Irofulven
CAS No.	187277-46-9
Molecular Formula	C15H20O4
Molecular Weight	264.32 g/mol
Synonyms	6-Hydroxymethylacylfulvene; HMAF; MGI 114; NSC 683863; (1aR,4S,4aR,7R,7aR,7bS)-1a,4,7-Trihydroxy-7-(hydroxymethyl)-1,1,4a,7b-tetramethyl-2,3,4,4a,5,6,7,7a-octahydro-1aH-cyclopropa[3,4]benz[1,2-e]azulen-9-one; Acylfulvene derivative
EINECS	Contact for details

Quality Control

Our Irofulven is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory submissions in drug development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.